CovidV2, new, Analysis, bibRecord, 000416

Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.

Identifieur interne : 000416 ( new/Analysis ); précédent : 000415; suivant : 000417

Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.

Auteurs : Fengxiang Song ; Nannan Shi ; Fei Shan ; Zhiyong Zhang ; Jie Shen ; Hongzhou Lu ; Yun Ling ; Yebin Jiang ; Yuxin Shi

Source :

Radiology [ 1527-1315 ] ; 2020.

RBID : pubmed:32027573

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Chine (épidémiologie), Facteurs de l'âge, Femelle, Fièvre (étiologie), Humains, Infections à coronavirus (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (imagerie diagnostique), Jeune adulte, Mâle, Numération des leucocytes, Pneumopathie virale (), Pneumopathie virale (anatomopathologie), Pneumopathie virale (imagerie diagnostique), Poumon (anatomopathologie), Poumon (imagerie diagnostique), Réaction de polymérisation en chaine en temps réel, Tomodensitométrie, Toux (étiologie), Études rétrospectives.
MESH :
- anatomopathologie : Infections à coronavirus, Pneumopathie virale, Poumon.
- imagerie diagnostique : Infections à coronavirus, Pneumopathie virale, Poumon.
- épidémiologie : Chine.
- étiologie : Fièvre, Toux.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Femelle, Humains, Infections à coronavirus, Jeune adulte, Mâle, Numération des leucocytes, Pneumopathie virale, Réaction de polymérisation en chaine en temps réel, Tomodensitométrie, Études rétrospectives.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Betacoronavirus (isolation & purification), China (epidemiology), Coronavirus Infections (complications), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (pathology), Cough (etiology), Female, Fever (etiology), Humans, Leukocyte Count, Lung (diagnostic imaging), Lung (pathology), Male, Middle Aged, Pneumonia, Viral (complications), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (pathology), Real-Time Polymerase Chain Reaction, Retrospective Studies, Tomography, X-Ray Computed, Young Adult.
MESH :
- geographic , epidemiology : China.
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Coronavirus Infections, Lung, Pneumonia, Viral.
- etiology : Cough, Fever.
- isolation & purification : Betacoronavirus.
- pathology : Coronavirus Infections, Lung, Pneumonia, Viral.
- Adolescent, Adult, Age Factors, Female, Humans, Leukocyte Count, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Retrospective Studies, Tomography, X-Ray Computed, Young Adult.

Abstract

BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated.ResultsFifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocyte count. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients, and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement, while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer (431 of 712 lesions vs 129 of 612 lesions; P < .001). Patients older than 50 years had more consolidated lung lesions than did those aged 50 years or younger (212 of 470 vs 198 of 854; P < .001). Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients.ConclusionPatients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posterior lungs on CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia.© RSNA, 2020.

DOI: 10.1148/radiol.2020200274
PubMed: 32027573

Affiliations:

Links to Exploration step

pubmed:32027573

Le document en format XML

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<author><name sortKey="Jiang, Yebin" sort="Jiang, Yebin" uniqKey="Jiang Y" first="Yebin" last="Jiang">Yebin Jiang</name>
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<author><name sortKey="Zhang, Zhiyong" sort="Zhang, Zhiyong" uniqKey="Zhang Z" first="Zhiyong" last="Zhang">Zhiyong Zhang</name>
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<author><name sortKey="Jiang, Yebin" sort="Jiang, Yebin" uniqKey="Jiang Y" first="Yebin" last="Jiang">Yebin Jiang</name>
<affiliation><nlm:affiliation>From the Departments of Radiology (F. Song, N.S., F. Shan, Z.Z., J.S., Y.S.) and Infectious Disease (H.L., Y.L.), Shanghai Public Health Clinical Center, No. 2501 Caolang Road, Jinshan District, Shanghai 201508, China; Department of the Principal's Office, Fudan University, Shanghai, China (Z.Z.); Cancer Center, University of Michigan, Ann Arbor, Mich (Y.J.); and Shanghai Key Laboratory of Molecular Imaging, Shanghai, China (Y.S.).</nlm:affiliation>
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<author><name sortKey="Shi, Yuxin" sort="Shi, Yuxin" uniqKey="Shi Y" first="Yuxin" last="Shi">Yuxin Shi</name>
<affiliation><nlm:affiliation>From the Departments of Radiology (F. Song, N.S., F. Shan, Z.Z., J.S., Y.S.) and Infectious Disease (H.L., Y.L.), Shanghai Public Health Clinical Center, No. 2501 Caolang Road, Jinshan District, Shanghai 201508, China; Department of the Principal's Office, Fudan University, Shanghai, China (Z.Z.); Cancer Center, University of Michigan, Ann Arbor, Mich (Y.J.); and Shanghai Key Laboratory of Molecular Imaging, Shanghai, China (Y.S.).</nlm:affiliation>
<wicri:noCountry code="subField">China (Y.S.).</wicri:noCountry>
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<front><div type="abstract" xml:lang="en">BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated.ResultsFifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocyte count. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients, and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement, while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer (431 of 712 lesions vs 129 of 612 lesions; <i>P</i>
 < .001). Patients older than 50 years had more consolidated lung lesions than did those aged 50 years or younger (212 of 470 vs 198 of 854; <i>P</i>
 < .001). Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients.ConclusionPatients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posterior lungs on CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia.© RSNA, 2020.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Jiang, Yebin" sort="Jiang, Yebin" uniqKey="Jiang Y" first="Yebin" last="Jiang">Yebin Jiang</name>
<name sortKey="Ling, Yun" sort="Ling, Yun" uniqKey="Ling Y" first="Yun" last="Ling">Yun Ling</name>
<name sortKey="Lu, Hongzhou" sort="Lu, Hongzhou" uniqKey="Lu H" first="Hongzhou" last="Lu">Hongzhou Lu</name>
<name sortKey="Shan, Fei" sort="Shan, Fei" uniqKey="Shan F" first="Fei" last="Shan">Fei Shan</name>
<name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name>
<name sortKey="Shi, Nannan" sort="Shi, Nannan" uniqKey="Shi N" first="Nannan" last="Shi">Nannan Shi</name>
<name sortKey="Shi, Yuxin" sort="Shi, Yuxin" uniqKey="Shi Y" first="Yuxin" last="Shi">Yuxin Shi</name>
<name sortKey="Song, Fengxiang" sort="Song, Fengxiang" uniqKey="Song F" first="Fengxiang" last="Song">Fengxiang Song</name>
<name sortKey="Zhang, Zhiyong" sort="Zhang, Zhiyong" uniqKey="Zhang Z" first="Zhiyong" last="Zhang">Zhiyong Zhang</name>
</noCountry>
</tree>
</affiliations>
</record>

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Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.

Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.

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